618.9K XNAS Volume
XNAS 19 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 159.74 per share. | 07 Mar 2025 | 2,039 | 251,041 (0%) | 0% | 159.7 | 325,710 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 159.74 per share. | 07 Mar 2025 | 1,070 | 52,450 (0%) | 0% | 159.7 | 170,922 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 159.74 per share. | 07 Mar 2025 | 1,431 | 73,861 (0%) | 0% | 159.7 | 228,588 | Common Stock |
| Mauro Premutico | SVP & CLO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 159.74 per share. | 07 Mar 2025 | 1,438 | 38,528 (0%) | 0% | 159.7 | 229,706 | Common Stock |
| Brian Millard | VP/CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 159.74 per share. | 07 Mar 2025 | 509 | 15,651 (0%) | 0% | 159.7 | 81,308 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 148.85 per share. | 04 Mar 2025 | 1,634 | 253,080 (0%) | 0% | 148.9 | 243,221 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 148.85 per share. | 04 Mar 2025 | 857 | 53,520 (0%) | 0% | 148.8 | 127,564 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 148.85 per share. | 04 Mar 2025 | 1,147 | 75,292 (0%) | 0% | 148.9 | 170,731 | Common Stock |
| Mauro Premutico | SVP & CLO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 148.85 per share. | 04 Mar 2025 | 1,152 | 39,966 (0%) | 0% | 148.8 | 171,475 | Common Stock |
| Brian Millard | VP/CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 148.85 per share. | 04 Mar 2025 | 577 | 16,160 (0%) | 0% | 148.8 | 85,886 | Common Stock |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2025 | 314 | 9,049 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2025 | 314 | 0 (0%) | 0% | 0 | Common Stock | |
| Brian Millard | VP/CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Feb 2025 | 4,593 | 16,737 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 145.02 per share. | 16 Feb 2025 | 7,863 | 240,936 (0%) | 0% | 145.0 | 1,140,292 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2025 | 18,538 | 248,799 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 145.02 per share. | 16 Feb 2025 | 3,117 | 230,261 (0%) | 0% | 145.0 | 452,027 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2025 | 7,348 | 233,378 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 142.50 per share. | 16 Feb 2025 | 1,917 | 226,030 (0%) | 0% | 142.5 | 273,173 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2025 | 13,778 | 254,714 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 142.50 per share. | 16 Feb 2025 | 744 | 42,134 (0%) | 0% | 142.5 | 106,020 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2025 | 3,197 | 45,331 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 145.02 per share. | 16 Feb 2025 | 1,635 | 43,696 (0%) | 0% | 145.0 | 237,108 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2025 | 8,066 | 51,762 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 145.02 per share. | 16 Feb 2025 | 3,379 | 48,383 (0%) | 0% | 145.0 | 490,023 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2025 | 5,994 | 54,377 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 142.50 per share. | 16 Feb 2025 | 889 | 55,735 (0%) | 0% | 142.5 | 126,683 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2025 | 9,671 | 76,439 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 145.02 per share. | 16 Feb 2025 | 4,950 | 66,768 (0%) | 0% | 145.0 | 717,849 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2025 | 13,013 | 71,718 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 145.02 per share. | 16 Feb 2025 | 2,188 | 58,705 (0%) | 0% | 145.0 | 317,304 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2025 | 5,158 | 60,893 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | SVP & CLO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 145.02 per share. | 16 Feb 2025 | 2,198 | 29,210 (0%) | 0% | 145.0 | 318,754 | Common Stock |
| Mauro Premutico | SVP & CLO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2025 | 10,013 | 39,223 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | SVP & CLO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 145.02 per share. | 16 Feb 2025 | 5,545 | 33,678 (0%) | 0% | 145.0 | 804,136 | Common Stock |
| Mauro Premutico | SVP & CLO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2025 | 7,440 | 41,118 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | SVP & CLO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2025 | 3,969 | 31,408 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | SVP & CLO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 142.50 per share. | 16 Feb 2025 | 1,375 | 27,439 (0%) | 0% | 142.5 | 195,938 | Common Stock |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2024 | 314 | 82,476 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2024 | 314 | 119,686 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2024 | 314 | 314 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2024 | 314 | 98,030 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2024 | 314 | 6,586 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2024 | 314 | 6,586 (0%) | 0% | 0 | Common Stock | |
| Joan Lau | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2024 | 314 | 1,039 (0%) | 0% | 0 | Common Stock | |
| Nigel Brown | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2024 | 314 | 1,039 (0%) | 0% | 0 | Common Stock | |
| Rosenblatt Sidney D. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Dec 2024 | 314 | 135,242 (0%) | 0% | 0 | Common Stock | |
| Rosenblatt D. Sidney | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Dec 2024 | 3,400 | 134,928 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 16 Dec 2024 | 942 | 0 (0%) | 0% | 0 | Common Stock | |
| Elias C. Richard | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 16 Dec 2024 | 942 | 8,735 (0%) | 0% | 0 | Common Stock | |
| Lacerte Lawrence | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 03 Dec 2024 | 3,000 | 119,372 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 20 Nov 2024 | 4,667 | 227,947 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 20 Nov 2024 | 2,012 | 5,033 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 20 Nov 2024 | 4,667 | 7,045 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Purchase of securities on an exchange or from another person at price $ 180.89 per share. | 04 Nov 2024 | 742 | 122,372 (0%) | 0% | 180.9 | 134,220 | Common Stock |
| Sidney D. Rosenblatt | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Oct 2024 | 15,822 | 3,520 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Oct 2024 | 15,822 | 138,328 (0%) | 0% | 0 | Common Stock | |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2024 | 314 | 82,162 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2024 | 314 | 121,630 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2024 | 314 | 122,506 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2024 | 314 | 942 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2024 | 314 | 97,716 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2024 | 314 | 6,272 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2024 | 314 | 6,272 (0%) | 0% | 0 | Common Stock | |
| Joan Lau | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2024 | 314 | 725 (0%) | 0% | 0 | Common Stock | |
| Nigel Brown | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2024 | 314 | 725 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 11 Sep 2024 | 6,000 | 122,192 (0%) | 0% | 0 | Common Stock | |
| Brian Millard | VP/CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 184.62 per share. | 06 Sep 2024 | 1,760 | 12,144 (0%) | 0% | 184.6 | 324,931 | Common Stock |
| Richard C. Elias | Director | Sale of securities on an exchange or to another person at price $ 192.60 per share. | 29 Aug 2024 | 5,064 | 4,439 (0%) | 0% | 192.6 | 975,326 | Common Stock |
| Lawrence Lacerte | Director | Purchase of securities on an exchange or from another person at price $ 187.99 per share. | 28 Aug 2024 | 1,000 | 121,316 (0%) | 0% | 188.0 | 187,990 | Common Stock |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Jul 2024 | 3,280 | 11,616 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Jul 2024 | 3,280 | 628 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Jul 2024 | 3,823 | 7,793 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Jul 2024 | 3,823 | 9,503 (0%) | 0% | 0 | Common Stock | |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jun 2024 | 314 | 81,848 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jun 2024 | 314 | 120,316 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jun 2024 | 314 | 128,192 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jun 2024 | 314 | 3,908 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jun 2024 | 314 | 97,402 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jun 2024 | 314 | 5,958 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jun 2024 | 314 | 5,958 (0%) | 0% | 0 | Common Stock | |
| Joan Lau | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jun 2024 | 314 | 411 (0%) | 0% | 0 | Common Stock | |
| Nigel Brown | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jun 2024 | 314 | 411 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 13 May 2024 | 516 | 0 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 13 May 2024 | 516 | 8,336 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | EVP & Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 175.00 per share. | 08 May 2024 | 10,358 | 56,624 (0%) | 0% | 175 | 1,812,650 | Common Stock |
| Mauro Premutico | SVP & CLO | Sale of securities on an exchange or to another person at price $ 177.50 per share. | 07 May 2024 | 2,400 | 30,744 (0%) | 0% | 177.5 | 426,000 | Common Stock |
| Mauro Premutico | SVP & CLO | Sale of securities on an exchange or to another person at price $ 176.39 per share. | 07 May 2024 | 1,168 | 33,144 (0%) | 0% | 176.4 | 206,024 | Common Stock |
| Mauro Premutico | SVP & CLO | Sale of securities on an exchange or to another person at price $ 175.30 per share. | 07 May 2024 | 2,633 | 34,312 (0%) | 0% | 175.3 | 461,565 | Common Stock |
| Mauro Premutico | SVP & CLO | Sale of securities on an exchange or to another person at price $ 178.24 per share. | 07 May 2024 | 2,001 | 28,743 (0%) | 0% | 178.2 | 356,658 | Common Stock |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Mar 2024 | 314 | 81,534 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Mar 2024 | 314 | 120,002 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Mar 2024 | 314 | 3,594 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Mar 2024 | 314 | 97,088 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Mar 2024 | 314 | 5,644 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Mar 2024 | 314 | 5,644 (0%) | 0% | 0 | Common Stock | |
| Joan Lau | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Mar 2024 | 97 | 97 (0%) | 0% | 0 | Common Stock | |
| Nigel Brown | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Mar 2024 | 97 | 97 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Mar 2024 | 314 | 127,878 (0%) | 0% | 0 | Common Stock | |
| C. Keith Hartley | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 Mar 2024 | 50 | 81,220 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | SVP & CLO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 1,259 | 39,014 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | SVP & CLO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 172.74 per share. | 07 Mar 2024 | 1,438 | 36,879 (0%) | 0% | 172.7 | 248,400 | Common Stock |
| Brian Millard | VP/CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 172.74 per share. | 07 Mar 2024 | 354 | 13,904 (0%) | 0% | 172.7 | 61,150 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 2,331 | 226,170 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 172.74 per share. | 07 Mar 2024 | 2,039 | 223,143 (0%) | 0% | 172.7 | 352,217 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 172.74 per share. | 07 Mar 2024 | 988 | 225,182 (0%) | 0% | 172.7 | 170,667 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 1,014 | 44,363 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 172.74 per share. | 07 Mar 2024 | 1,070 | 42,775 (0%) | 0% | 172.7 | 184,832 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 172.74 per share. | 07 Mar 2024 | 518 | 43,845 (0%) | 0% | 172.7 | 89,479 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 172.74 per share. | 07 Mar 2024 | 1,431 | 66,852 (0%) | 0% | 172.7 | 247,191 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 172.74 per share. | 07 Mar 2024 | 693 | 68,283 (0%) | 0% | 172.7 | 119,709 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 1,636 | 68,976 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | SVP & CLO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 172.74 per share. | 07 Mar 2024 | 697 | 38,317 (0%) | 0% | 172.7 | 120,400 | Common Stock |
| Brian Millard | VP/CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2024 | 3,850 | 14,258 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 174.68 per share. | 02 Mar 2024 | 2,636 | 209,595 (0%) | 0% | 174.7 | 460,456 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 4,663 | 214,258 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 174.68 per share. | 02 Mar 2024 | 1,978 | 212,280 (0%) | 0% | 174.7 | 345,517 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 11,559 | 223,839 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | SVP of Tech Commercialization | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 2,028 | 39,053 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | SVP of Tech Commercialization | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 5,029 | 43,349 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 174.68 per share. | 02 Mar 2024 | 733 | 38,320 (0%) | 0% | 174.7 | 128,040 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 174.68 per share. | 02 Mar 2024 | 1,253 | 37,025 (0%) | 0% | 174.7 | 218,874 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 8,113 | 67,340 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 174.68 per share. | 02 Mar 2024 | 1,850 | 57,113 (0%) | 0% | 174.7 | 323,158 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 3,273 | 60,386 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 174.68 per share. | 02 Mar 2024 | 1,159 | 59,227 (0%) | 0% | 174.7 | 202,454 | Common Stock |
| Mauro Premutico | SVP & CLO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 2,518 | 32,907 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | SVP & CLO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 174.68 per share. | 02 Mar 2024 | 1,858 | 30,389 (0%) | 0% | 174.7 | 324,555 | Common Stock |
| Mauro Premutico | SVP & CLO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 174.68 per share. | 02 Mar 2024 | 1,394 | 31,513 (0%) | 0% | 174.7 | 243,504 | Common Stock |
| Mauro Premutico | SVP & CLO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 6,242 | 37,755 (0%) | 0% | 0 | Common Stock | |
| C. Richard Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Feb 2024 | 212 | 755 (0%) | 0% | 0 | Common Stock | |
| Richard Elias C. | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Feb 2024 | 212 | 7,820 (0%) | 0% | 0 | Common Stock | |
| Lacerte Lawrence | Director | Sale of securities on an exchange or to another person at price $ 171.95 per share. | 27 Feb 2024 | 3,956 | 119,688 (0%) | 0% | 171.9 | 680,234 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 169.90 per share. | 27 Feb 2024 | 1,342 | 125,346 (0%) | 0% | 169.9 | 228,006 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 170.99 per share. | 27 Feb 2024 | 1,702 | 123,644 (0%) | 0% | 171.0 | 291,025 | Common Stock |
| DuFour Janice M. | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 181.76 per share. | 16 Feb 2024 | 731 | 38,278 (0%) | 0% | 181.8 | 132,867 | Common Stock |
| V. Steven Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 181.76 per share. | 16 Feb 2024 | 1,237 | 212,231 (0%) | 0% | 181.8 | 224,837 | Common Stock |
| Premutico Mauro | SVP & CLO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 181.76 per share. | 16 Feb 2024 | 1,001 | 32,247 (0%) | 0% | 181.8 | 181,942 | Common Stock |
| J. Brown Julia | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 181.76 per share. | 16 Feb 2024 | 881 | 58,963 (0%) | 0% | 181.8 | 160,131 | Common Stock |
| C. Keith Hartley | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 15 Feb 2024 | 300 | 81,270 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Jan 2024 | 200 | 126,688 (0%) | 0% | 0 | Common Stock | |
| Richard Elias C. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2023 | 472 | 3,280 (0%) | 0% | 0 | Common Stock | |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2023 | 472 | 81,570 (0%) | 0% | 0 | Common Stock | |
| Gemmill H. Elizabeth | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2023 | 472 | 96,774 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2023 | 472 | 126,888 (0%) | 0% | 0 | Common Stock | |
| M. Joseph Celia | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2023 | 472 | 5,330 (0%) | 0% | 0 | Common Stock | |
| J. Cynthia Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2023 | 472 | 5,330 (0%) | 0% | 0 | Common Stock | |
| Sidney Rosenblatt D. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2023 | 472 | 126,427 (0%) | 0% | 0 | Common Stock | |
| D. Rosenblatt Sidney | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 22 Dec 2023 | 2,800 | 125,955 (0%) | 0% | 0 | Common Stock | |
| Abramson V. Steven | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 06 Dec 2023 | 9,302 | 14,312 (0%) | 0% | 0 | Common Stock | |
| V. Steven Abramson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 06 Dec 2023 | 9,302 | 210,868 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Sale of securities on an exchange or to another person at price $ 158.14 per share. | 09 Aug 2023 | 1,014 | 5,767 (0%) | 0% | 158.1 | 160,354 | Common Stock |
| Richard C. Elias | Director | Sale of securities on an exchange or to another person at price $ 157.21 per share. | 09 Aug 2023 | 986 | 6,781 (0%) | 0% | 157.2 | 155,009 | Common Stock |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 21 Jul 2023 | 1,782 | 2,781 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 21 Jul 2023 | 1,782 | 7,767 (0%) | 0% | 0 | Common Stock | |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 472 | 80,626 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 472 | 125,944 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 472 | 120,111 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 472 | 2,336 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 472 | 95,830 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 472 | 4,386 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 472 | 4,386 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | EVP & Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 151.24 per share. | 06 Jun 2023 | 849 | 59,818 (0%) | 0% | 151.2 | 128,403 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 150.53 per share. | 06 Jun 2023 | 2,601 | 60,667 (0%) | 0% | 150.5 | 391,529 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 150.14 per share. | 06 Jun 2023 | 1,764 | 63,268 (0%) | 0% | 150.1 | 264,847 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 136.73 per share. | 09 May 2023 | 15,000 | 125,472 (0%) | 0% | 136.7 | 2,050,950 | Common Stock |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 472 | 80,154 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 472 | 140,472 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 472 | 119,839 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 155.13 per share. | 31 Mar 2023 | 200 | 119,639 (0%) | 0% | 155.1 | 31,026 | Common Stock |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Mar 2023 | 1,418 | 4,563 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Mar 2023 | 246 | 543 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Mar 2023 | 246 | 5,985 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Mar 2023 | 1,476 | 6,231 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Mar 2023 | 1,418 | 7,707 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 472 | 1,864 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 472 | 95,358 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 472 | 3,914 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 472 | 3,914 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 144.89 per share. | 22 Mar 2023 | 1,361 | 119,367 (0%) | 0% | 144.9 | 197,195 | Common Stock |
| Sidney D. Rosenblatt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Mar 2023 | 3,209 | 120,728 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 144.89 per share. | 22 Mar 2023 | 1,361 | 201,373 (0%) | 0% | 144.9 | 197,195 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Mar 2023 | 3,209 | 202,734 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | SVP of Tech Commercialization | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Mar 2023 | 1,396 | 39,598 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 144.89 per share. | 22 Mar 2023 | 714 | 38,884 (0%) | 0% | 144.9 | 103,451 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 144.89 per share. | 22 Mar 2023 | 955 | 64,838 (0%) | 0% | 144.9 | 138,370 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Mar 2023 | 2,252 | 65,793 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | SVP & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 144.89 per share. | 22 Mar 2023 | 959 | 33,056 (0%) | 0% | 144.9 | 138,950 | Common Stock |
| Mauro Premutico | SVP & GM, Licensing | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Mar 2023 | 1,733 | 34,015 (0%) | 0% | 0 | Common Stock | |
| Brian Millard | VP/CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2023 | 3,607 | 11,908 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 140.62 per share. | 06 Mar 2023 | 3,629 | 117,519 (0%) | 0% | 140.6 | 510,310 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 14,425 | 199,525 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 140.62 per share. | 06 Mar 2023 | 3,629 | 185,100 (0%) | 0% | 140.6 | 510,310 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 140.62 per share. | 06 Mar 2023 | 1,171 | 33,830 (0%) | 0% | 140.6 | 164,666 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 6,275 | 38,202 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 140.62 per share. | 06 Mar 2023 | 1,903 | 31,927 (0%) | 0% | 140.6 | 267,600 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 140.62 per share. | 06 Mar 2023 | 2,547 | 53,416 (0%) | 0% | 140.6 | 358,159 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 10,125 | 63,541 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 140.62 per share. | 06 Mar 2023 | 2,171 | 55,963 (0%) | 0% | 140.6 | 305,286 | Common Stock |
| Mauro Premutico | SVP & GM, Licensing | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 7,790 | 32,282 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | SVP & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 140.62 per share. | 06 Mar 2023 | 1,417 | 27,050 (0%) | 0% | 140.6 | 199,259 | Common Stock |
| Mauro Premutico | SVP & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 140.62 per share. | 06 Mar 2023 | 2,558 | 24,492 (0%) | 0% | 140.6 | 359,706 | Common Stock |
| Sidney D. Rosenblatt | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 138.97 per share. | 02 Mar 2023 | 2,636 | 121,148 (0%) | 0% | 139.0 | 366,325 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 138.97 per share. | 02 Mar 2023 | 2,636 | 188,729 (0%) | 0% | 139.0 | 366,325 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 138.97 per share. | 02 Mar 2023 | 977 | 35,001 (0%) | 0% | 139.0 | 135,774 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 138.97 per share. | 02 Mar 2023 | 1,353 | 58,134 (0%) | 0% | 139.0 | 188,026 | Common Stock |
| Mauro Premutico | SVP & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 138.97 per share. | 02 Mar 2023 | 1,859 | 28,467 (0%) | 0% | 139.0 | 258,345 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 137.56 per share. | 28 Feb 2023 | 21,098 | 140,000 (0%) | 0% | 137.6 | 2,902,241 | Common Stock |
| Sidney D. Rosenblatt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 19,265 | 123,784 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 133.44 per share. | 16 Feb 2023 | 1,906 | 138,988 (0%) | 0% | 133.4 | 254,337 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 133.44 per share. | 16 Feb 2023 | 1,912 | 191,365 (0%) | 0% | 133.4 | 255,137 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 133.44 per share. | 16 Feb 2023 | 737 | 35,978 (0%) | 0% | 133.4 | 98,345 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 133.44 per share. | 16 Feb 2023 | 885 | 59,487 (0%) | 0% | 133.4 | 118,094 | Common Stock |
| Mauro Premutico | SVP & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 133.44 per share. | 16 Feb 2023 | 1,371 | 30,326 (0%) | 0% | 133.4 | 182,946 | Common Stock |
| Sidney D. Rosenblatt | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 37,922 | 144,311 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 1,578 | 41,451 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 2,573 | 43,029 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 6,063 | 45,602 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 2,688 | 51,665 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 37,922 | 54,353 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 2,573 | 140,894 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 9,253 | 138,321 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 2,800 | 147,574 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 6,063 | 150,374 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 9,283 | 35,605 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 1,505 | 23,614 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 10,486 | 25,119 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 9,283 | 193,277 (0%) | 0% | 0 | Common Stock | |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Dec 2022 | 366 | 79,682 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Dec 2022 | 366 | 161,098 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Dec 2022 | 366 | 1,392 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Dec 2022 | 366 | 94,886 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Dec 2022 | 366 | 3,442 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Dec 2022 | 366 | 3,442 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 110.49 per share. | 14 Nov 2022 | 13,020 | 160,732 (0%) | 0% | 110.5 | 1,438,580 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 109.76 per share. | 14 Nov 2022 | 16,980 | 173,752 (0%) | 0% | 109.8 | 1,863,725 | Common Stock |
| Cynthia J. Comparin | Director | Sale of securities on an exchange or to another person at price $ 109.88 per share. | 14 Nov 2022 | 3,628 | 0 (0%) | 0% | 109.9 | 398,645 | Common Stock |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2022 | 366 | 79,316 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2022 | 366 | 190,732 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2022 | 366 | 1,026 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2022 | 297 | 660 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2022 | 297 | 297 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2022 | 366 | 94,520 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2022 | 366 | 3,076 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2022 | 366 | 3,076 (0%) | 0% | 0 | Common Stock | |
| Brian Millard | VP/CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Sep 2022 | 8,301 | 8,301 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director, EVP and CFO | Sale of securities on an exchange or to another person at price $ 108.65 per share. | 01 Sep 2022 | 5,886 | 106,335 (0%) | 0% | 108.7 | 639,514 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Sale of securities on an exchange or to another person at price $ 107.94 per share. | 01 Sep 2022 | 21,576 | 112,221 (0%) | 0% | 107.9 | 2,328,913 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Sale of securities on an exchange or to another person at price $ 105.71 per share. | 01 Sep 2022 | 11,500 | 144,835 (0%) | 0% | 105.7 | 1,215,665 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Sale of securities on an exchange or to another person at price $ 106.75 per share. | 01 Sep 2022 | 11,038 | 133,797 (0%) | 0% | 106.8 | 1,178,307 | Common Stock |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Aug 2022 | 2,183 | 7,944 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Sale of securities on an exchange or to another person at price $ 123.89 per share. | 10 Aug 2022 | 600 | 5,680 (0%) | 0% | 123.9 | 74,334 | Common Stock |
| Richard C. Elias | Director | Sale of securities on an exchange or to another person at price $ 123.86 per share. | 10 Aug 2022 | 1,400 | 6,289 (0%) | 0% | 123.9 | 173,404 | Common Stock |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Aug 2022 | 1,963 | 7,689 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Aug 2022 | 1,963 | 5,981 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Aug 2022 | 2,183 | 5,726 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 115.16 per share. | 09 Aug 2022 | 10,000 | 190,732 (0%) | 0% | 115.2 | 1,151,600 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 116.67 per share. | 09 Aug 2022 | 366 | 190,366 (0%) | 0% | 116.7 | 42,701 | Common Stock |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2022 | 366 | 78,950 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2022 | 366 | 200,732 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Jun 2022 | 3,543 | 3,543 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2022 | 366 | 957 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Jun 2022 | 3,543 | 10,127 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2022 | 366 | 94,154 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2022 | 366 | 2,710 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2022 | 366 | 2,710 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | SVP & GM, Licensing | Sale of securities on an exchange or to another person at price $ 114.27 per share. | 12 May 2022 | 7,618 | 31,600 (0%) | 0% | 114.3 | 870,509 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2022 | 2,494 | 157,366 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director, EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 163.29 per share. | 05 Apr 2022 | 1,057 | 156,309 (0%) | 0% | 163.3 | 172,598 | Common Stock |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2022 | 1,208 | 89,649 (0%) | 0% | 0 | Common Stock | |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Payment of exercise price or tax liability using portion of securities received from the company at price $ 163.29 per share. | 05 Apr 2022 | 512 | 89,137 (0%) | 0% | 163.3 | 83,604 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 05 Apr 2022 | 2,248 | 182,510 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2022 | 2,494 | 185,058 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 163.29 per share. | 05 Apr 2022 | 1,057 | 184,001 (0%) | 0% | 163.3 | 172,598 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 05 Apr 2022 | 2,248 | 44,785 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | SVP of Tech Commercialization | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2022 | 966 | 37,080 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 163.29 per share. | 05 Apr 2022 | 494 | 36,586 (0%) | 0% | 163.3 | 80,665 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2022 | 1,752 | 61,070 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 163.29 per share. | 05 Apr 2022 | 743 | 60,327 (0%) | 0% | 163.3 | 121,324 | Common Stock |
| Mauro Premutico | SVP & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 163.29 per share. | 05 Apr 2022 | 656 | 39,218 (0%) | 0% | 163.3 | 107,118 | Common Stock |
| Mauro Premutico | SVP & GM, Licensing | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2022 | 1,186 | 39,874 (0%) | 0% | 0 | Common Stock | |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2022 | 366 | 78,584 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Mar 2022 | 7,826 | 206,432 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2022 | 366 | 200,366 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Mar 2022 | 6,432 | 200,000 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Mar 2022 | 200 | 214,258 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2022 | 366 | 591 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2022 | 366 | 93,788 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2022 | 366 | 2,344 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2022 | 366 | 2,344 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director, EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2022 | 312 | 164,400 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director, EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 3,629 | 154,858 (0%) | 0% | 156.1 | 566,378 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 5,429 | 158,487 (0%) | 0% | 156.1 | 847,304 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 352 | 163,916 (0%) | 0% | 156.1 | 54,937 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 132 | 164,268 (0%) | 0% | 156.1 | 20,601 | Common Stock |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2022 | 151 | 88,873 (0%) | 0% | 0 | Common Stock | |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 198 | 88,441 (0%) | 0% | 156.1 | 30,902 | Common Stock |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 170 | 88,639 (0%) | 0% | 156.1 | 26,532 | Common Stock |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.06 per share. | 05 Mar 2022 | 64 | 88,809 (0%) | 0% | 156.1 | 9,988 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2022 | 312 | 189,804 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 132 | 189,672 (0%) | 0% | 156.1 | 20,601 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 352 | 189,320 (0%) | 0% | 156.1 | 54,937 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 5,429 | 183,891 (0%) | 0% | 156.1 | 847,304 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 3,629 | 180,262 (0%) | 0% | 156.1 | 566,378 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 164 | 39,304 (0%) | 0% | 156.1 | 25,595 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 1,903 | 36,092 (0%) | 0% | 156.1 | 297,001 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 1,309 | 37,995 (0%) | 0% | 156.1 | 204,296 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 61 | 39,468 (0%) | 0% | 156.1 | 9,520 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2022 | 121 | 39,529 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | EVP & Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2022 | 219 | 64,270 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 2,547 | 59,213 (0%) | 0% | 156.1 | 397,510 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 2,171 | 61,760 (0%) | 0% | 156.1 | 338,828 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 247 | 63,931 (0%) | 0% | 156.1 | 38,549 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 92 | 64,178 (0%) | 0% | 156.1 | 14,358 | Common Stock |
| Mauro Premutico | SVP & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 2,558 | 38,635 (0%) | 0% | 156.1 | 399,227 | Common Stock |
| Mauro Premutico | SVP & GM, Licensing | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2022 | 149 | 42,910 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | SVP & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 82 | 42,828 (0%) | 0% | 156.1 | 12,798 | Common Stock |
| Mauro Premutico | SVP & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 218 | 42,610 (0%) | 0% | 156.1 | 34,023 | Common Stock |
| Mauro Premutico | SVP & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.07 per share. | 05 Mar 2022 | 1,417 | 41,193 (0%) | 0% | 156.1 | 221,151 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 159.07 per share. | 02 Mar 2022 | 2,637 | 164,088 (0%) | 0% | 159.1 | 419,468 | Common Stock |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Payment of exercise price or tax liability using portion of securities received from the company at price $ 159.07 per share. | 02 Mar 2022 | 111 | 88,722 (0%) | 0% | 159.1 | 17,657 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 159.07 per share. | 02 Mar 2022 | 2,637 | 189,492 (0%) | 0% | 159.1 | 419,468 | Common Stock |
| Janice M. DuFour | SVP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 159.07 per share. | 02 Mar 2022 | 1,241 | 39,408 (0%) | 0% | 159.1 | 197,406 | Common Stock |
| Julia J. Brown | EVP & Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 159.07 per share. | 02 Mar 2022 | 1,850 | 64,051 (0%) | 0% | 159.1 | 294,280 | Common Stock |
| Mauro Premutico | SVP & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 159.07 per share. | 02 Mar 2022 | 1,859 | 42,761 (0%) | 0% | 159.1 | 295,711 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2022 | 13,482 | 166,725 (0%) | 0% | 0 | Common Stock | |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2022 | 736 | 88,833 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 16 Feb 2022 | 4,676 | 47,033 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2022 | 13,482 | 192,129 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 16 Feb 2022 | 3,899 | 51,709 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 16 Feb 2022 | 4,676 | 178,647 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 16 Feb 2022 | 3,899 | 173,971 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | SVP of Tech Commercialization | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2022 | 5,865 | 40,649 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | EVP & Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2022 | 9,463 | 65,901 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | SVP & GM, Licensing | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2022 | 7,281 | 44,620 (0%) | 0% | 0 | Common Stock | |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2021 | 226 | 81,193 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2021 | 226 | 217,233 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2021 | 2 | 5,829 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2021 | 927 | 15,922 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2021 | 2,250 | 13,670 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2021 | 2 | 15,920 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2021 | 927 | 5,827 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2021 | 226 | 451 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2021 | 226 | 93,197 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2021 | 226 | 1,753 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2021 | 226 | 1,753 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 208.38 per share. | 01 Sep 2021 | 18,987 | 223,020 (0%) | 0% | 208.4 | 3,956,511 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 209.13 per share. | 01 Sep 2021 | 6,013 | 217,007 (0%) | 0% | 209.1 | 1,257,499 | Common Stock |
| Elizabeth H. Gemmill | Director | Sale of securities on an exchange or to another person at price $ 205.38 per share. | 10 Aug 2021 | 3,869 | 92,971 (0%) | 0% | 205.4 | 794,615 | Common Stock |
| Elizabeth H. Gemmill | Director | Sale of securities on an exchange or to another person at price $ 202.17 per share. | 10 Aug 2021 | 4,261 | 103,210 (0%) | 0% | 202.2 | 861,446 | Common Stock |
| Elizabeth H. Gemmill | Director | Sale of securities on an exchange or to another person at price $ 204.73 per share. | 10 Aug 2021 | 5,318 | 96,840 (0%) | 0% | 204.7 | 1,088,754 | Common Stock |
| Elizabeth H. Gemmill | Director | Sale of securities on an exchange or to another person at price $ 202.80 per share. | 10 Aug 2021 | 1,052 | 102,158 (0%) | 0% | 202.8 | 213,346 | Common Stock |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2021 | 226 | 80,968 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2021 | 226 | 242,008 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2021 | 226 | 107,472 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2021 | 226 | 1,528 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2021 | 226 | 1,528 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 225.00 per share. | 28 Jun 2021 | 22,007 | 56,397 (0%) | 0% | 225 | 4,951,575 | Common Stock |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 12 May 2021 | 4,200 | 16,849 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 12 May 2021 | 764 | 12,649 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 12 May 2021 | 4,200 | 4,900 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 May 2021 | 226 | 226 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 12 May 2021 | 764 | 0 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 194.92 per share. | 11 May 2021 | 400 | 251,382 (0%) | 0% | 194.9 | 77,968 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 200.39 per share. | 11 May 2021 | 1,993 | 241,782 (0%) | 0% | 200.4 | 399,377 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 199.31 per share. | 11 May 2021 | 1,991 | 243,775 (0%) | 0% | 199.3 | 396,826 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 198.48 per share. | 11 May 2021 | 2,916 | 245,766 (0%) | 0% | 198.5 | 578,768 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 197.48 per share. | 11 May 2021 | 1,300 | 248,682 (0%) | 0% | 197.5 | 256,724 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 196.30 per share. | 11 May 2021 | 1,400 | 249,982 (0%) | 0% | 196.3 | 274,820 | Common Stock |
| Mauro Premutico | VP, Legal & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 229.25 per share. | 16 Apr 2021 | 10,305 | 37,264 (0%) | 0% | 229.2 | 2,362,421 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Apr 2021 | 1,487 | 153,833 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director, EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 242.10 per share. | 06 Apr 2021 | 630 | 153,203 (0%) | 0% | 242.1 | 152,523 | Common Stock |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Apr 2021 | 720 | 92,669 (0%) | 0% | 0 | Common Stock | |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Payment of exercise price or tax liability using portion of securities received from the company at price $ 242.10 per share. | 06 Apr 2021 | 272 | 92,397 (0%) | 0% | 242.1 | 65,851 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 242.10 per share. | 06 Apr 2021 | 630 | 170,001 (0%) | 0% | 242.1 | 152,523 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Apr 2021 | 1,487 | 170,631 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | VP of Tech Commercialization | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Apr 2021 | 576 | 35,012 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | VP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 242.10 per share. | 06 Apr 2021 | 294 | 34,718 (0%) | 0% | 242.1 | 71,177 | Common Stock |
| Julia J. Brown | Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 242.10 per share. | 06 Apr 2021 | 443 | 78,404 (0%) | 0% | 242.1 | 107,250 | Common Stock |
| Julia J. Brown | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Apr 2021 | 1,045 | 78,847 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | VP, Legal & GM, Licensing | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Apr 2021 | 707 | 47,957 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | VP, Legal & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 242.10 per share. | 06 Apr 2021 | 388 | 47,569 (0%) | 0% | 242.1 | 93,935 | Common Stock |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2021 | 226 | 80,742 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2021 | 226 | 107,246 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2021 | 226 | 1,302 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2021 | 226 | 1,302 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director, EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2021 | 18,649 | 161,735 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director, EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 352 | 161,383 (0%) | 0% | 189.1 | 66,556 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 420 | 160,963 (0%) | 0% | 189.1 | 79,414 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 3,629 | 157,334 (0%) | 0% | 189.1 | 686,171 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 5,427 | 151,907 (0%) | 0% | 189.1 | 1,026,137 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2021 | 744 | 152,651 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director, EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 315 | 152,336 (0%) | 0% | 189.1 | 59,560 | Common Stock |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2021 | 360 | 92,190 (0%) | 0% | 0 | Common Stock | |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 113 | 92,077 (0%) | 0% | 189.1 | 21,366 | Common Stock |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 128 | 91,949 (0%) | 0% | 189.1 | 24,202 | Common Stock |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2021 | 1,017 | 92,069 (0%) | 0% | 0 | Common Stock | |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 108 | 91,961 (0%) | 0% | 189.1 | 20,421 | Common Stock |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 131 | 91,830 (0%) | 0% | 189.1 | 24,769 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 315 | 169,107 (0%) | 0% | 189.1 | 59,560 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2021 | 18,649 | 178,506 (0%) | 0% | 0 | Common Stock | |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 352 | 178,154 (0%) | 0% | 189.1 | 66,556 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 420 | 177,734 (0%) | 0% | 189.1 | 79,414 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 3,629 | 174,105 (0%) | 0% | 189.1 | 686,171 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 5,427 | 168,678 (0%) | 0% | 189.1 | 1,026,137 | Common Stock |
| Steven V. Abramson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2021 | 744 | 169,422 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | VP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 121 | 39,266 (0%) | 0% | 189.1 | 22,879 | Common Stock |
| Janice M. DuFour | VP of Tech Commercialization | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2021 | 288 | 39,387 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | VP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 138 | 39,099 (0%) | 0% | 189.1 | 26,093 | Common Stock |
| Janice M. DuFour | VP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 117 | 39,237 (0%) | 0% | 189.1 | 22,122 | Common Stock |
| Janice M. DuFour | VP of Tech Commercialization | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2021 | 8,112 | 39,354 (0%) | 0% | 0 | Common Stock | |
| Janice M. DuFour | VP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 199.81 per share. | 02 Mar 2021 | 3,499 | 34,422 (0%) | 0% | 199.8 | 699,135 | Common Stock |
| Janice M. DuFour | VP of Tech Commercialization | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 1,345 | 37,921 (0%) | 0% | 189.1 | 254,313 | Common Stock |
| Julia J. Brown | Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 160 | 90,182 (0%) | 0% | 189.1 | 30,253 | Common Stock |
| Julia J. Brown | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2021 | 523 | 90,515 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 150 | 90,365 (0%) | 0% | 189.1 | 28,362 | Common Stock |
| Julia J. Brown | Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 2,024 | 88,341 (0%) | 0% | 189.1 | 382,698 | Common Stock |
| Julia J. Brown | Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 199.81 per share. | 02 Mar 2021 | 10,605 | 77,736 (0%) | 0% | 199.8 | 2,118,985 | Common Stock |
| Julia J. Brown | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2021 | 13,089 | 90,342 (0%) | 0% | 0 | Common Stock | |
| Julia J. Brown | Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 02 Mar 2021 | 190 | 89,992 (0%) | 0% | 189.1 | 35,925 | Common Stock |
| Cynthia J. Comparin | Director | Purchase of securities on an exchange or from another person at price $ 209.85 per share. | 23 Feb 2021 | 458 | 3,628 (0%) | 0% | 209.8 | 96,111 | Common Stock |
| Cynthia J. Comparin | Director | Purchase of securities on an exchange or from another person at price $ 208.97 per share. | 23 Feb 2021 | 448 | 3,170 (0%) | 0% | 209.0 | 93,619 | Common Stock |
| Cynthia J. Comparin | Director | Purchase of securities on an exchange or from another person at price $ 207.86 per share. | 23 Feb 2021 | 412 | 2,722 (0%) | 0% | 207.9 | 85,638 | Common Stock |
| Cynthia J. Comparin | Director | Purchase of securities on an exchange or from another person at price $ 206.15 per share. | 23 Feb 2021 | 320 | 2,310 (0%) | 0% | 206.2 | 65,968 | Common Stock |
| Cynthia J. Comparin | Director | Purchase of securities on an exchange or from another person at price $ 205.18 per share. | 23 Feb 2021 | 492 | 1,990 (0%) | 0% | 205.2 | 100,949 | Common Stock |
| Cynthia J. Comparin | Director | Purchase of securities on an exchange or from another person at price $ 203.94 per share. | 23 Feb 2021 | 170 | 1,498 (0%) | 0% | 203.9 | 34,670 | Common Stock |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Feb 2021 | 1,536 | 11,885 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2021 | 226 | 764 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Feb 2021 | 1,536 | 9,100 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | VP, Legal & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 27 Jan 2021 | 258 | 49,612 (0%) | 0% | 189.1 | 48,783 | Common Stock |
| Mauro Premutico | VP, Legal & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 27 Jan 2021 | 215 | 49,870 (0%) | 0% | 189.1 | 40,652 | Common Stock |
| Mauro Premutico | VP, Legal & GM, Licensing | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2021 | 10,070 | 50,085 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | VP, Legal & GM, Licensing | Gift of securities by or to the insider at price $ 0.00 per share. | 27 Jan 2021 | 9,351 | 40,015 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | VP, Legal & GM, Licensing | Gift of securities by or to the insider at price $ 0.00 per share. | 27 Jan 2021 | 9,351 | 9,351 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | VP, Legal & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 27 Jan 2021 | 210 | 49,756 (0%) | 0% | 189.1 | 39,707 | Common Stock |
| Mauro Premutico | VP, Legal & GM, Licensing | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2021 | 354 | 49,966 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | VP, Legal & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.08 per share. | 27 Jan 2021 | 2,539 | 47,217 (0%) | 0% | 189.1 | 480,074 | Common Stock |
| Lawrence Lacerte | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 14 Jan 2021 | 3,949 | 251,556 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jan 2021 | 226 | 251,782 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director, EVP and CFO | Gift of securities by or to the insider at price $ 0.00 per share. | 14 Dec 2020 | 2,800 | 147,932 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director, EVP and CFO | Sale of securities on an exchange or to another person at price $ 234.80 per share. | 14 Dec 2020 | 1,074 | 0 (0%) | 0% | 234.8 | 252,175 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Sale of securities on an exchange or to another person at price $ 233.96 per share. | 14 Dec 2020 | 11,856 | 1,074 (0%) | 0% | 234.0 | 2,773,830 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Sale of securities on an exchange or to another person at price $ 233.13 per share. | 14 Dec 2020 | 27,193 | 12,930 (0%) | 0% | 233.1 | 6,339,504 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Sale of securities on an exchange or to another person at price $ 232.08 per share. | 14 Dec 2020 | 10,233 | 40,123 (0%) | 0% | 232.1 | 2,374,875 | Common Stock |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Nov 2020 | 2,725 | 5,673 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Sale of securities on an exchange or to another person at price $ 210.50 per share. | 10 Nov 2020 | 177 | 0 (0%) | 0% | 210.5 | 37,259 | Common Stock |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Nov 2020 | 1,891 | 13,421 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Nov 2020 | 2,725 | 15,312 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Nov 2020 | 1,891 | 7,564 (0%) | 0% | 0 | Common Stock | |
| C. Keith Hartley | Director | Sale of securities on an exchange or to another person at price $ 213.72 per share. | 05 Nov 2020 | 7,500 | 82,167 (0%) | 0% | 213.7 | 1,602,900 | Common Stock |
| C. Keith Hartley | Director | Sale of securities on an exchange or to another person at price $ 212.07 per share. | 05 Nov 2020 | 2,500 | 89,667 (0%) | 0% | 212.1 | 530,175 | Common Stock |
| Janice M. DuFour | VP of Tech Commercialization | Sale of securities on an exchange or to another person at price $ 201.49 per share. | 04 Nov 2020 | 1,100 | 36,548 (0%) | 0% | 201.5 | 221,639 | Common Stock |
| Janice M. DuFour | VP of Tech Commercialization | Sale of securities on an exchange or to another person at price $ 207.64 per share. | 04 Nov 2020 | 300 | 31,222 (0%) | 0% | 207.6 | 62,292 | Common Stock |
| Janice M. DuFour | VP of Tech Commercialization | Sale of securities on an exchange or to another person at price $ 206.92 per share. | 04 Nov 2020 | 1,924 | 31,522 (0%) | 0% | 206.9 | 398,114 | Common Stock |
| Janice M. DuFour | VP of Tech Commercialization | Sale of securities on an exchange or to another person at price $ 205.51 per share. | 04 Nov 2020 | 500 | 33,446 (0%) | 0% | 205.5 | 102,755 | Common Stock |
| Janice M. DuFour | VP of Tech Commercialization | Sale of securities on an exchange or to another person at price $ 205.00 per share. | 04 Nov 2020 | 806 | 33,946 (0%) | 0% | 205 | 165,230 | Common Stock |
| Janice M. DuFour | VP of Tech Commercialization | Sale of securities on an exchange or to another person at price $ 203.77 per share. | 04 Nov 2020 | 904 | 34,752 (0%) | 0% | 203.8 | 184,208 | Common Stock |
| Janice M. DuFour | VP of Tech Commercialization | Sale of securities on an exchange or to another person at price $ 202.52 per share. | 04 Nov 2020 | 892 | 35,656 (0%) | 0% | 202.5 | 180,648 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 199.97 per share. | 03 Nov 2020 | 2,111 | 255,936 (0%) | 0% | 200.0 | 422,137 | Common Stock |
| Julia J. Brown | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 199.64 per share. | 12 Oct 2020 | 14,461 | 80,272 (0%) | 0% | 199.6 | 2,886,994 | Common Stock |
| Julia J. Brown | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 203.72 per share. | 12 Oct 2020 | 67 | 77,253 (0%) | 0% | 203.7 | 13,649 | Common Stock |
| Julia J. Brown | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 202.36 per share. | 12 Oct 2020 | 158 | 77,320 (0%) | 0% | 202.4 | 31,973 | Common Stock |
| Julia J. Brown | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 201.93 per share. | 12 Oct 2020 | 459 | 77,478 (0%) | 0% | 201.9 | 92,686 | Common Stock |
| Julia J. Brown | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 200.59 per share. | 12 Oct 2020 | 2,335 | 77,937 (0%) | 0% | 200.6 | 468,378 | Common Stock |
| Julia J. Brown | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 198.76 per share. | 12 Oct 2020 | 4,156 | 94,733 (0%) | 0% | 198.8 | 826,047 | Common Stock |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2020 | 269 | 92,167 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2020 | 1,387 | 257,778 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2020 | 269 | 258,047 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2020 | 538 | 0 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2020 | 177 | 177 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2020 | 3,125 | 18,037 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2020 | 4,672 | 21,162 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2020 | 177 | 2,948 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2020 | 3,125 | 3,125 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2020 | 4,134 | 0 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2020 | 269 | 269 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2020 | 269 | 119,751 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2020 | 269 | 807 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2020 | 269 | 807 (0%) | 0% | 0 | Common Stock | |
| Mauro Premutico | VP, Legal & GM, Licensing | Sale of securities on an exchange or to another person at price $ 187.18 per share. | 12 Aug 2020 | 3,102 | 54,175 (0%) | 0% | 187.2 | 580,632 | Common Stock |
| Mauro Premutico | VP, Legal & GM, Licensing | Sale of securities on an exchange or to another person at price $ 188.87 per share. | 12 Aug 2020 | 600 | 49,335 (0%) | 0% | 188.9 | 113,322 | Common Stock |
| Mauro Premutico | VP, Legal & GM, Licensing | Sale of securities on an exchange or to another person at price $ 188.27 per share. | 12 Aug 2020 | 4,240 | 49,935 (0%) | 0% | 188.3 | 798,265 | Common Stock |
| Mauro Premutico | VP, Legal & GM, Licensing | Sale of securities on an exchange or to another person at price $ 186.14 per share. | 12 Aug 2020 | 1,722 | 57,277 (0%) | 0% | 186.1 | 320,533 | Common Stock |
| Mauro Premutico | VP, Legal & GM, Licensing | Sale of securities on an exchange or to another person at price $ 185.45 per share. | 12 Aug 2020 | 1,401 | 58,999 (0%) | 0% | 185.4 | 259,815 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 184.18 per share. | 11 Aug 2020 | 1,594 | 259,265 (0%) | 0% | 184.2 | 293,583 | Common Stock |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 184.82 per share. | 11 Aug 2020 | 100 | 259,165 (0%) | 0% | 184.8 | 18,482 | Common Stock |
| C. Keith Hartley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2020 | 269 | 91,898 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2020 | 269 | 260,859 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Other type of transaction at price $ 0.00 per share. | 30 Jun 2020 | 4,134 | 4,134 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2020 | 269 | 538 (0%) | 0% | 0 | Common Stock | |
| Richard C. Elias | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Jun 2020 | 2,700 | 16,490 (0%) | 0% | 0 | Common Stock | |
| Elizabeth H. Gemmill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2020 | 269 | 119,482 (0%) | 0% | 0 | Common Stock | |
| Cynthia J. Comparin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2020 | 269 | 538 (0%) | 0% | 0 | Common Stock | |
| Celia M. Joseph | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2020 | 269 | 538 (0%) | 0% | 0 | Common Stock | |
| Lawrence Lacerte | Director | Sale of securities on an exchange or to another person at price $ 149.75 per share. | 18 May 2020 | 1,253 | 260,590 (0%) | 0% | 149.8 | 187,637 | Common Stock |
| Mauro Premutico | VP, Legal & GM, Licensing | Payment of exercise price or tax liability using portion of securities received from the company at price $ 142.89 per share. | 16 Apr 2020 | 10,305 | 60,328 (0%) | 0% | 142.9 | 1,472,481 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 134.75 per share. | 07 Apr 2020 | 1,729 | 227,325 (0%) | 0% | 134.8 | 232,983 | Common Stock |
| Sidney D. Rosenblatt | Director, EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Apr 2020 | 4,078 | 229,054 (0%) | 0% | 0 | Common Stock | |
| Sidney D. Rosenblatt | Director, EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 134.75 per share. | 07 Apr 2020 | 21,210 | 206,115 (0%) | 0% | 134.8 | 2,858,048 | Common Stock |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Apr 2020 | 1,974 | 96,889 (0%) | 0% | 0 | Common Stock | |
| Sherwin I. Seligsohn | Director, Chairman of Board and Founder | Payment of exercise price or tax liability using portion of securities received from the company at price $ 134.75 per share. | 07 Apr 2020 | 837 | 96,052 (0%) | 0% | 134.8 | 112,786 | Common Stock |